Molecular weight : Recombinant human GH is a protein composed of 22.9 kDa, 205 amino residues.
Description : GH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus.
Figure 1. SDS-PAGE analysis of recombinant HGH. Samples were loaded in 15% SDS-polyacrylamide gel and stained with coomassie blue. Lane MWM: Molecular weight marker (kDa); Lane 1 and 2: contains 0.05 ug and 0.3 ug of Agrenvec recombinant HGH. Lane 3 and 4: immune-detection with specific anti-human GH 0.05 ug and 0.3 ug respectively.
Biological Activity: The biological activity of human Growth Hormone is measured by cell proliferation using Nb2-11 cells. ED50 ≤ 0.04-0.1 ng/mL
Human recombinant protein expressed in Nicotiana.
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