Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein
Activin A is 100% identical between human, mouse, rat, pig, cow and cat proteins.
Description: Activins are homodimers or heterodimers of the various β subunit isoforms, belonging to the TGFβ family. Mature Activin A has two 116 amino acids residues βA subunits (βA – βA).
Biological functions: Activin exhibits a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, hematopoiesis, reproductive physiology, cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activins plays a key role in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells known to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.
Molecular weight: 27.4 kDa disulfide-linked homodimers of two βA chains, each containing 116 amino residues.
Biological Activity: The biological activity of Activin A is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation. Cell proliferation was measured by MTT method. . ED50 ≤ 5 ng/ml.
Human recombinant protein expressed in Nicotiana benthamiana.
This product contains no animal–derived components or impurities. Animal Free product.
Bulk sizes are available upon request.
For R&D purposes only. Purchaser must determine the suitability of the product(s) for their particular use.